A covalently linked phenanthridine–ruthenium(II) complex as a RNA probe

Naphtali A. O’Connor; Nathan Stevens; Diana Samaroo; Marissa R. Solomon; Angel A. Martí; Joanne Dyer; Harshad Vishwasrao; Daniel L. Akins; Eric R. Kandel; Nicholas J. Turro

doi:10.1039/B900290A

A covalently linked phenanthridine–ruthenium(ii) complex as a RNA probe†

Naphtali A. O’Connor,^a Nathan Stevens,^b Diana Samaroo,^c Marissa R. Solomon,^b Angel A. Martí,^d Joanne Dyer,^b Harshad Vishwasrao,^e Daniel L. Akins,^f Eric R. Kandel^e and Nicholas J. Turro*^b

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* Corresponding authors

^a Department of Chemistry, Lehman College of The City University of New York, Bronx, USA
E-mail: naphtali.oconnor@lehman.cuny.edu

^b Department of Chemistry, Columbia University, 3000 Broadway, New York, USA
E-mail: njt3@columbia.edu

^c Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, USA

^d Department of Chemistry, Rice University, Houston, USA

^e HHMI, Columbia University College of Physicians and Surgeons, New York, USA

^f Department of Chemistry, City College of The City University of New York, New York, USA

Abstract

A phenanthridine derivative covalently linked to a ruthenium complex yields an imaging probe whose fluorescence intensity and lifetime change substantially in the presence of RNA.

Chemical Communications

A covalently linked phenanthridine–ruthenium(ii) complex as a RNA probe†

Abstract

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A covalently linked phenanthridine–ruthenium(II) complex as a RNA probe

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