Issue 16, 2009
From the journal:

Chemical Communications

Phosphoramidite accelerated copper(i)-catalyzed [3 + 2] cycloadditions of azides and alkynes†‡

Lachlan S. Campbell-Verduyn,a   Leila Mirfeizi,b   Rudi A. Dierckx,b   Philip H. Elsinga*b  and  Ben L. Feringa*a  

* Corresponding authors

a Stratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands
E-mail: b.l.feringa@rug.nl
Fax: +31 50 363 4278
Tel: +31 50 363 4296

b Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
E-mail: p.h.elsinga@ngmb.umcg.nl
Fax: +31 50 3696750
Tel: +31 50 3614850

Abstract

Monodentate phosphoramidite ligands are used to accelerate the copper(I)-catalyzed 1,3-dipolar cycloaddition of azides and alkynes (CuAAC) rapidly yielding a wide variety of functionalized 1,4-disubstituted-1,2,3-triazoles; Cu(I) and Cu(II) salts both function as the copper source in aqueous solution to provide excellent yields.

Graphical abstract: Phosphoramidite accelerated copper(i)-catalyzed [3 + 2] cycloadditions of azides and alkynes

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Article information

DOI
https://doi.org/10.1039/B822994E
Article type
Communication
Submitted
22 Dec 2008
Accepted
05 Mar 2009
First published
19 Mar 2009

Chem. Commun., 2009, 2139-2141

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Phosphoramidite accelerated copper(I)-catalyzed [3 + 2] cycloadditions of azides and alkynes

L. S. Campbell-Verduyn, L. Mirfeizi, R. A. Dierckx, P. H. Elsinga and B. L. Feringa, Chem. Commun., 2009, 2139 DOI: 10.1039/B822994E

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