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Issue 16, 2009
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Phosphoramidite accelerated copper(i)-catalyzed [3 + 2] cycloadditions of azides and alkynes

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Abstract

Monodentate phosphoramidite ligands are used to accelerate the copper(I)-catalyzed 1,3-dipolar cycloaddition of azides and alkynes (CuAAC) rapidly yielding a wide variety of functionalized 1,4-disubstituted-1,2,3-triazoles; Cu(I) and Cu(II) salts both function as the copper source in aqueous solution to provide excellent yields.

Graphical abstract: Phosphoramidite accelerated copper(i)-catalyzed [3 + 2] cycloadditions of azides and alkynes

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Submitted
22 Dec 2008
Accepted
05 Mar 2009
First published
19 Mar 2009

Chem. Commun., 2009, 2139-2141
Article type
Communication

Phosphoramidite accelerated copper(I)-catalyzed [3 + 2] cycloadditions of azides and alkynes

L. S. Campbell-Verduyn, L. Mirfeizi, R. A. Dierckx, P. H. Elsinga and B. L. Feringa, Chem. Commun., 2009, 2139
DOI: 10.1039/B822994E

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