Molecular combo of photodynamic therapeutic agent silicon(IV) phthalocyanine and anticancer drug cisplatin

Jiafei Mao; Yangmiao Zhang; Jianhui Zhu; Changli Zhang; Zijian Guo

doi:10.1039/B817968A

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Molecular combo of photodynamic therapeutic agent silicon(iv) phthalocyanine and anticancer drug cisplatin†

Jiafei Mao,^a Yangmiao Zhang,^a Jianhui Zhu,^a Changli Zhang^a and Zijian Guo*^a

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* Corresponding authors

^a State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
E-mail: zguo@nju.edu.cn
Fax: +86 25 83224539
Tel: +86-025-83686218

Abstract

The combination of a red light PDT agent and a Pt(II)-based chemotherapeutic drug at the molecular level maintains the intrinsic functions of each unit; the conjugated complexes exhibit remarkable photocytoxicity and demonstrate potential to serve as agents for DNA-targeting PDT as well as red light photochemotherapy.

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Supplementary files

Synthesis, characterization of the complexes, experimentaldetails, photophysical data for 1 and 2, CD spectra of CT-DNA incubated with 1 or 2, gel electrophoresis of pUC19 DNA incubated with 1 and 2, 2D [¹H,¹⁵N] HSQC NMR spectra of ¹⁵N-1 and ¹⁵N-2, the cytotoxicity and its SD values of a cytotoxicityexperiment and the fluorescence images of Hoechst 33342 stainedHeLa cells which were incubated with complex 1 PDF (4286K)

Article information

DOI: https://doi.org/10.1039/B817968A
Article type: Communication
Submitted: 14 Oct 2008
Accepted: 15 Dec 2008
First published: 19 Jan 2009

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Chem. Commun., 2009, 908-910

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Molecular combo of photodynamic therapeutic agent silicon(IV) phthalocyanine and anticancer drug cisplatin

J. Mao, Y. Zhang, J. Zhu, C. Zhang and Z. Guo, Chem. Commun., 2009, 908 DOI: 10.1039/B817968A

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Chemical Communications

Molecular combo of photodynamic therapeutic agent silicon(iv) phthalocyanine and anticancer drug cisplatin†

Abstract

Supplementary files

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Molecular combo of photodynamic therapeutic agent silicon(IV) phthalocyanine and anticancer drug cisplatin

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