Issue 3, 2009
From the journal:

Chemical Communications

From DNA cross-linking to peptide labeling: on the versatility of the furan-oxidation–conjugation strategy†

Annelies Deceunincka  and  Annemieke Madder*a  

* Corresponding authors

a Laboratory for Organic and Biomimetic Chemistry, Department of Organic Chemistry, Krijgslaan 281, Belgium
E-mail: annemieke.madder@ugent.be
Fax: (+)32-9-264 49 98

Abstract

Based on the incorporation of commercially available N-Fmoc-furylalanine, a new method for peptide labeling is proposed, relying on the selective oxidative transformation of the furan moiety into a reactive aldehyde and subsequent reductive amination.

Graphical abstract: From DNA cross-linking to peptide labeling: on the versatility of the furan-oxidation–conjugation strategy

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Article information

DOI
https://doi.org/10.1039/B817447D
Article type
Communication
Submitted
06 Oct 2008
Accepted
11 Nov 2008
First published
01 Dec 2008

Chem. Commun., 2009, 340-342

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From DNA cross-linking to peptide labeling: on the versatility of the furan-oxidation–conjugation strategy

A. Deceuninck and A. Madder, Chem. Commun., 2009, 340 DOI: 10.1039/B817447D

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