Issue 6, 2009
From the journal:

Chemical Communications

Protease responsive nanoprobes with tethered fluorogenic peptidyl 3-arylcoumarin substrates†

Katharina Welser,ab   Jakob Grilj,c   Eric Vauthey,c   Jonathan W. Aylott*b  and  Weng C. Chan*a  

* Corresponding authors

a School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, UK
E-mail: weng.chan@nottingham.ac.uk

b School of Pharmacy, Boots Science Building, University of Nottingham, University Park, Nottingham, UK
E-mail: jon.aylott@nottingham.ac.uk

c Département de Chimie-physique, Université de Genève, 30 Quai Ernest Ansermet, Genève 4, Switzerland

Abstract

Protease responsive nanosensors were obtained by the attachment of unique green fluorescent bifunctional 3-arylcoumarin-derived fluorogenic substrates to poly(acrylamide-co-N-(3-aminopropyl)methacrylamide) nanoparticles, in which proteolysis results in substantial signal amplification.

Graphical abstract: Protease responsive nanoprobes with tethered fluorogenic peptidyl 3-arylcoumarin substrates

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Article information

DOI
https://doi.org/10.1039/B816637D
Article type
Communication
Submitted
23 Sep 2008
Accepted
13 Nov 2008
First published
08 Dec 2008

Chem. Commun., 2009, 671-673

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Protease responsive nanoprobes with tethered fluorogenic peptidyl 3-arylcoumarin substrates

K. Welser, J. Grilj, E. Vauthey, J. W. Aylott and W. C. Chan, Chem. Commun., 2009, 671 DOI: 10.1039/B816637D

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