Issue 5, 2009

Synergic asymmetric organocatalysis (SAOc) of Cinchonaalkaloids and secondary amines in the synthesis of bicyclo[2.2.2]octan-2-ones

Abstract

A synergistic effect between chiral secondary and tertiary amines gives access to bicyclo[2.2.2]octan-2-ones with up to 90% ee and >10 : 1 dr.

Graphical abstract: Synergic asymmetric organocatalysis (SAOc) of Cinchonaalkaloids and secondary amines in the synthesis of bicyclo[2.2.2]octan-2-ones

Supplementary files

Article information

Article type
Communication
Submitted
22 Sep 2008
Accepted
19 Nov 2008
First published
08 Dec 2008

Chem. Commun., 2009, 597-599

Synergic asymmetric organocatalysis (SAOc) of Cinchonaalkaloids and secondary amines in the synthesis of bicyclo[2.2.2]octan-2-ones

M. Bella, D. M. S. Schietroma, P. P. Cusella, T. Gasperi and V. Visca, Chem. Commun., 2009, 597 DOI: 10.1039/B816550E

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