Issue 10, 2009
From the journal:

Analyst

A versatile approach for assaying in vitro metallodrug metabolism using CE hyphenated with ICP-MS†

Jan K. Abramski,a   Lidia S. Foteeva,b   Kasia Pawlak,a   Andrei R. Timerbaev*b  and  Maciej Jarosza  

* Corresponding authors

a Chair of Analytical Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland

b Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Kosygin St. 19, 119991 Moscow, Russia
E-mail: andrei.timerbaev@univie.ac.at
Fax: +7-495-938-2054
Tel: +7-495-939-7035

Abstract

An informative analytical method, based on commercially available capillary electrophoresis (CE), inductively coupled plasma mass spectrometry (ICP-MS) and interface units, was developed for ascertaining possible metabolic transformations of metal-based drugs. Using a novel anticancer gallium compound, it was demonstrated that the drug remains intact in the simulated intestine juice. On the contrary, it undergoes a marked change in speciation (mostly, due to binding to transferrin) in human serum.

Graphical abstract: A versatile approach for assaying in vitro metallodrug metabolism using CE hyphenated with ICP-MS

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Article information

DOI
https://doi.org/10.1039/B913954K
Article type
Communication
Submitted
16 Jul 2009
Accepted
11 Aug 2009
First published
14 Aug 2009

Analyst, 2009,134, 1999-2002

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A versatile approach for assaying in vitro metallodrug metabolism using CE hyphenated with ICP-MS

J. K. Abramski, L. S. Foteeva, K. Pawlak, A. R. Timerbaev and M. Jarosz, Analyst, 2009, 134, 1999 DOI: 10.1039/B913954K

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