Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 17, 2009
Previous Article Next Article

Phase behavior of multicomponent membranes: Experimental and computational techniques

Author affiliations

Abstract

Recent developments in biology seems to indicate that the Fluid Mosaic model of membrane proposed by Singer and Nicolson, with lipid bilayer functioning only as medium to support protein machinery, may be too simple to be realistic. Many protein functions are now known to depend on the composition of the membrane. Experiments indicate that biomembranes of eukaryotic cells may be laterally organized into small nanoscopic domains. This inplane organization is expected to play an important role in a variety of physiological functions such as signaling, recruitment of specific proteins and endocytosis. However, mainly because of their complexity, the precise in-plane organization of lipids and proteins and their stability in biological membranes remain difficult to elucidate. This has reiterated the importance of understanding the equilibrium phase behavior and the kinetics of fluid multicomponent lipid membranes. Current increase in interest in the domain formation in multicomponent membranes also stems from the experiments demonstrating liquid ordered-liquid disordered coexistence in mixtures of lipids and cholesterol and the success of several computational models in predicting their behavior. This review includes basic foundations on membrane model systems and experimental approaches applied in the membrane research area, stressing on recent advances in the experimental and computational techniques.

Graphical abstract: Phase behavior of multicomponent membranes: Experimental and computational techniques

Back to tab navigation

Article information


Submitted
29 Jan 2009
Accepted
16 Jun 2009
First published
28 Jul 2009

Soft Matter, 2009,5, 3234-3248
Article type
Review Article

Phase behavior of multicomponent membranes: Experimental and computational techniques

L. Bagatolli and P. B. Sunil Kumar, Soft Matter, 2009, 5, 3234
DOI: 10.1039/B901866B

Social activity

Search articles by author

Spotlight

Advertisements