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Issue 7, 2009
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Sensitized formation of oxidatively generated damage to cellular DNA by UVA radiation

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Abstract

The survey is aimed at critically reviewing information on the UVA-mediated oxidative reactions to cellular components with emphasis on DNA as the result of mostly photosensitized pathways. It appears clearly that UVA radiation is relatively much more efficient than UVB photons in inducing oxidative processes. The main UVA-induced oxidative degradation pathways of DNA are reported and discussed mechanistically. They are mostly rationalized in terms of a major contribution of singlet molecular oxygen (1O2) and to a lesser extent of hydroxyl radical (˙OH), that in the latter case originates from Fenton-type reactions. This leads to the predominant formation of 8-oxo-7,8-dihydroguanine together with smaller amounts of oxidized pyrimidine bases and DNA strand breaks in UVA-irradiated cells.

Graphical abstract: Sensitized formation of oxidatively generated damage to cellular DNA by UVA radiation

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Article information


Submitted
16 Mar 2009
Accepted
18 May 2009
First published
15 Jun 2009

Photochem. Photobiol. Sci., 2009,8, 903-911
Article type
Perspective

Sensitized formation of oxidatively generated damage to cellular DNA by UVA radiation

J. Cadet, T. Douki, J. Ravanat and P. Di Mascio, Photochem. Photobiol. Sci., 2009, 8, 903
DOI: 10.1039/B905343N

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