Issue 24, 2009

Towards an asymmetric synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin

Abstract

Studies towards the synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin are reported. The synthetic approach features an organocatalytic access to the α,α-disubstituted amino acid unit and results in the synthesis of an advanced intermediate which already contains all functionalities of fumimycin.

Graphical abstract: Towards an asymmetric synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin

Supplementary files

Article information

Article type
Communication
Submitted
10 Aug 2009
Accepted
05 Oct 2009
First published
19 Oct 2009

Org. Biomol. Chem., 2009,7, 5059-5062

Towards an asymmetric synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin

C. E. Hartmann, P. J. Gross, M. Nieger and S. Bräse, Org. Biomol. Chem., 2009, 7, 5059 DOI: 10.1039/B916372G

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