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Issue 24, 2009
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Towards an asymmetric synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin

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Abstract

Studies towards the synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin are reported. The synthetic approach features an organocatalytic access to the α,α-disubstituted amino acid unit and results in the synthesis of an advanced intermediate which already contains all functionalities of fumimycin.

Graphical abstract: Towards an asymmetric synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin

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Publication details

The article was received on 10 Aug 2009, accepted on 05 Oct 2009 and first published on 19 Oct 2009


Article type: Communication
DOI: 10.1039/B916372G
Org. Biomol. Chem., 2009,7, 5059-5062

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    Towards an asymmetric synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin

    C. E. Hartmann, P. J. Gross, M. Nieger and S. Bräse, Org. Biomol. Chem., 2009, 7, 5059
    DOI: 10.1039/B916372G

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