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Issue 9, 2009
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Triggering cryptic natural productbiosynthesis in microorganisms

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Natural products from microorganisms are a crucial source for novel therapeutics. Even so, it seems that many valuable compounds are overlooked when culturing microbes under standardized laboratory conditions. Many biosynthesis genes remain silent and such “cryptic” or “orphan” pathways are only activated under specific conditions. This report gives an overview on the strategies to trigger biosynthetic pathways to yield “cryptic natural products” through external cues, co-cultivation and genomic approaches such as genome-mining, epigenetic remodeling, and engineered pathway activation.

Graphical abstract: Triggering cryptic natural product biosynthesis in microorganisms

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Publication details

The article was received on 02 Dec 2008, accepted on 27 Jan 2009 and first published on 06 Mar 2009

Article type: Emerging Area
DOI: 10.1039/B821578B
Org. Biomol. Chem., 2009,7, 1753-1760

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    Triggering cryptic natural product biosynthesis in microorganisms

    K. Scherlach and C. Hertweck, Org. Biomol. Chem., 2009, 7, 1753
    DOI: 10.1039/B821578B

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