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Issue 13, 2009
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Synthesis and properties of a novel molecular beacon containing a benzene-phosphate backbone at its stem moiety

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Abstract

This paper describes the synthesis and properties of a novel molecular beacon (MB) containing a benzene-phosphate backbone at its stem moiety. The fluorescence intensity of MBs was found to stabilize by the introduction of the benzene-phosphate backbone at its stem moiety. Furthermore, an MB containing the benzene-phosphate backbone was more resistant to DNase I (endonuclease) than an MB comprising natural DNA and 2′-O-methyl-RNA. These results indicate that the MB with the benzene-phosphate backbone is superior as a molecular beacon as compared to the MB composed of natural DNA and 2′-O-methyl-RNA.

Graphical abstract: Synthesis and properties of a novel molecular beacon containing a benzene-phosphate backbone at its stem moiety

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Article information


Submitted
26 Jan 2009
Accepted
06 Apr 2009
First published
12 May 2009

Org. Biomol. Chem., 2009,7, 2761-2769
Article type
Paper

Synthesis and properties of a novel molecular beacon containing a benzene-phosphate backbone at its stem moiety

Y. Ueno, A. Kawamura, K. Takasu, S. Komatsuzaki, T. Kato, S. Kuboe, Y. Kitamura and Y. Kitade, Org. Biomol. Chem., 2009, 7, 2761 DOI: 10.1039/B901631G

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