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Issue 4, 2009
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Enzymatic synthesis of peptides on a solid support

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Abstract

We have previously shown that dipeptides can be synthesised in high yields from amino acids using protease catalysis in aqueous media, if the amino component is immobilised on porous PEGA resin (a copolymer of polyethylene glycol and polyacrylamide). Here we explore the scope of this methodology for using protected and glycosylated amino acids as well as the synthesis of longer peptides on resin and show that such a method can also be applied on non-porous surfaces, in particular on gold.

Graphical abstract: Enzymatic synthesis of peptides on a solid support

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Publication details

The article was received on 25 Sep 2008, accepted on 05 Nov 2008 and first published on 09 Dec 2008


Article type: Paper
DOI: 10.1039/B816847D
Org. Biomol. Chem., 2009,7, 665-670

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    Enzymatic synthesis of peptides on a solid support

    R. Haddoub, M. Dauner, F. A. Stefanowicz, V. Barattini, N. Laurent and S. L. Flitsch, Org. Biomol. Chem., 2009, 7, 665
    DOI: 10.1039/B816847D

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