Jump to main content
Jump to site search

Issue 11, 2009
Previous Article Next Article

Genomic basis for natural product biosynthetic diversity in the actinomycetes

Author affiliations

Abstract

Covering: up to mid-2009

The phylum Actinobacteria hosts diverse high G + C, Gram-positive bacteria that have evolved a complex chemical language of natural product chemistry to help navigate their fascinatingly varied lifestyles. To date, 71 Actinobacteria genomes have been completed and annotated, with the vast majority representing the Actinomycetales, which are the source of numerous antibiotics and other drugs from genera such as Streptomyces, Saccharopolyspora and Salinispora. These genomic analyses have illuminated the secondary metabolic proficiency of these microbes – underappreciated for years based on conventional isolation programs – and have helped set the foundation for a new natural product discovery paradigm based on genome mining. Trends in the secondary metabolomes of natural product-rich actinomycetes are highlighted in this review article, which contains 199 references.

Graphical abstract: Genomic basis for natural product biosynthetic diversity in the actinomycetes

  • This article is part of the themed collection: Genomics
Back to tab navigation

Publication details

The article was received on 03 Aug 2009 and first published on 01 Sep 2009


Article type: Review Article
DOI: 10.1039/B817069J
Nat. Prod. Rep., 2009,26, 1362-1384

  •   Request permissions

    Genomic basis for natural product biosynthetic diversity in the actinomycetes

    M. Nett, H. Ikeda and B. S. Moore, Nat. Prod. Rep., 2009, 26, 1362
    DOI: 10.1039/B817069J

Search articles by author

Spotlight

Advertisements