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Issue 11, 2009
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Genomic basis for natural product biosynthetic diversity in the actinomycetes

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Abstract

Covering: up to mid-2009

The phylum Actinobacteria hosts diverse high G + C, Gram-positive bacteria that have evolved a complex chemical language of natural product chemistry to help navigate their fascinatingly varied lifestyles. To date, 71 Actinobacteria genomes have been completed and annotated, with the vast majority representing the Actinomycetales, which are the source of numerous antibiotics and other drugs from genera such as Streptomyces, Saccharopolyspora and Salinispora. These genomic analyses have illuminated the secondary metabolic proficiency of these microbes – underappreciated for years based on conventional isolation programs – and have helped set the foundation for a new natural product discovery paradigm based on genome mining. Trends in the secondary metabolomes of natural product-rich actinomycetes are highlighted in this review article, which contains 199 references.

Graphical abstract: Genomic basis for natural product biosynthetic diversity in the actinomycetes

  • This article is part of the themed collection: Genomics
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Article information


Submitted
03 Aug 2009
First published
01 Sep 2009

Nat. Prod. Rep., 2009,26, 1362-1384
Article type
Review Article

Genomic basis for natural product biosynthetic diversity in the actinomycetes

M. Nett, H. Ikeda and B. S. Moore, Nat. Prod. Rep., 2009, 26, 1362
DOI: 10.1039/B817069J

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