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Issue 8, 2009
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New natural product biosynthetic chemistry discovered by genome mining

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Abstract

Covering: 2000 to 2008

Analyses of plant and microbial genome sequences have revealed many genes and gene clusters encoding proteins similar to those known to be involved in the biosynthesis of structurally-complex natural products. Many of these genes and gene clusters do not direct the production of known metabolites of the organism in which they are found. Others represent novel gene clusters that direct the biosynthesis of known natural products. This article highlights several examples of new biosynthetic chemistry discovered in the course of investigating such gene clusters.

Graphical abstract: New natural product biosynthetic chemistry discovered by genome mining

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Publication details

The article was received on 13 Mar 2009 and first published on 22 May 2009


Article type: Highlight
DOI: 10.1039/B713024B
Nat. Prod. Rep., 2009,26, 977-986

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    New natural product biosynthetic chemistry discovered by genome mining

    C. Corre and G. L. Challis, Nat. Prod. Rep., 2009, 26, 977
    DOI: 10.1039/B713024B

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