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Issue 12, 2009
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Modular logical modelling of the budding yeast cell cycle

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Abstract

Systems biologists are facing the difficult challenge of modelling and analysing regulatory networks encompassing numerous and diverse components and interactions. Furthermore, available data sets are often qualitative, which complicates the definition of truly quantitative models. In order to build comprehensive and predictive models, there is clearly a need for incremental strategies, enabling the progression from relatively small to large scale models. Leaning on former models, we have defined a logical model for three regulatory modules involved in the control of the mitotic cell cycle in budding yeast, namely the core cell cycle module, the morphogenetic checkpoint, and a module controlling the exit from mitosis. Consistency with available data has been assessed through a systematic analysis of model behaviours for various genetic backgrounds and other perturbations. Next, we take advantage of compositional facilities of the logical formalism to combine these three models in order to generate a single comprehensive model involving over thirty regulatory components. The resulting logical model preserves all relevant characteristics of the original modules, while enabling the simulation of more sophisticated experiments.

Graphical abstract: Modular logical modelling of the budding yeast cell cycle

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Supplementary files

Article information


Submitted
21 May 2009
Accepted
05 Jun 2009
First published
31 Jul 2009

Mol. BioSyst., 2009,5, 1787-1796
Article type
Paper

Modular logical modelling of the budding yeast cell cycle

A. Fauré, A. Naldi, F. Lopez, C. Chaouiya, A. Ciliberto and D. Thieffry, Mol. BioSyst., 2009, 5, 1787
DOI: 10.1039/B910101M

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