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Issue 12, 2009
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Stable G-quadruplexes are found outside nucleosome-bound regions

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Abstract

Unusual DNA structures such as four-stranded G-quadruplexes have been found to form in vivo and to play regulatory roles. However, since DNA is normally present as chromatin, with the double helix wrapped around histoneproteins, it is unclear how a G-quadruplex could form in such a region. Here, we show that regulatory G-quadruplexes found upstream of transcription start sites are in fact located in a region depleted of nucleosomes, and that in general in both Caenorhabditis elegans and humans, stable G-quadruplexes are located outside nucleosome-bound regions, hence making it easier for them to form in vivo.

Graphical abstract: Stable G-quadruplexes are found outside nucleosome-bound regions

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Article information


Submitted
24 Mar 2009
Accepted
15 Apr 2009
First published
14 May 2009

Mol. BioSyst., 2009,5, 1713-1719
Article type
Paper

Stable G-quadruplexes are found outside nucleosome-bound regions

H. M. Wong and J. L. Huppert, Mol. BioSyst., 2009, 5, 1713
DOI: 10.1039/B905848F

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