Issue 8, 2009
From the journal:

Molecular BioSystems

Mirror image phage display—a method to generate d-peptideligands for use in diagnostic or therapeutical applications

Susanne Aileen Funkea  and  Dieter Willbold*ab  

* Corresponding authors

a Forschungszentrum Jülich, Jülich, Germany

b Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Germany
E-mail: dieter.willbold@uni-duesseldorf.de
Fax: +49 2461 61 2023
Tel: +49 2461 61 2100

Abstract

Mirror image phage display is a straightforward approach to identify new potentially therapeutically active D-enantiomeric peptides. Such D-peptides are more resistant to proteolytic degradation compared to L-peptides. In this review, several examples of mirror image phage display derived D-peptides with therapeutical potential are introduced and discussed.

Graphical abstract: Mirror image phage display—a method to generate d-peptideligands for use in diagnostic or therapeutical applications

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Article information

DOI
https://doi.org/10.1039/B904138A
Article type
Review Article
Submitted
27 Feb 2009
Accepted
30 Apr 2009
First published
12 Jun 2009

Mol. BioSyst., 2009,5, 783-786

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Mirror image phage display—a method to generate D-peptideligands for use in diagnostic or therapeutical applications

S. A. Funke and D. Willbold, Mol. BioSyst., 2009, 5, 783 DOI: 10.1039/B904138A

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