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Issue 7, 2009
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Engineering and exploiting protein assemblies in synthetic biology

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Abstract

Many biologically relevant structures are formed by the self-assembly of identical protein units. Examples include virus capsids or cytoskeleton components. Synthetic biology can harness these bottom-up assemblies and expand their scope for applications in cell biology and biomedicine. Nanobiotechnology and materials science also stand to gain from assemblies with unique nanoscale periodicity. In these disciplines, the soft scaffolds can serve as templates to produce new metallic or inorganic materialsof predefined dimensions. This review article describes how the structure and function of biological assemblies has inspired researchers to develop engineered systems with designed properties for new biomolecular applications.

Graphical abstract: Engineering and exploiting protein assemblies in synthetic biology

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Publication details

The article was received on 05 Feb 2009, accepted on 11 Mar 2009 and first published on 07 May 2009


Article type: Review Article
DOI: 10.1039/B902440A
Mol. BioSyst., 2009,5, 723-732

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    Engineering and exploiting protein assemblies in synthetic biology

    D. Papapostolou and S. Howorka, Mol. BioSyst., 2009, 5, 723
    DOI: 10.1039/B902440A

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