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Issue 5, 2009
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A general map of iron metabolism and tissue-specific subnetworks†

Valerie Hower,ab   Pedro Mendes,bc   Frank M. Torti,ad   Reinhard Laubenbacher,b   Steven Akman,ad   Vladmir Shulaevb  and  Suzy V. Torti*ae  
Author affiliations

* Corresponding authors

a Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, USA

b Virginia Bioinformatics Institute, Blacksburg, USA

c School of Computer Science and Manchester Centre for Integrative Systems Biology, The University of Manchester, 131 Princess St., Manchester, UK

d Comprehensive Cancer Center, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, USA

e Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, USA
E-mail: storti@wfubmc.edu

Abstract

Iron is required for survival of mammalian cells. Recently, understanding of iron metabolism and trafficking has increased dramatically, revealing a complex, interacting network largely unknown just a few years ago. This provides an excellent model for systems biology development and analysis. The first step in such an analysis is the construction of a structural network of iron metabolism, which we present here. This network was created using CellDesigner version 3.5.2 and includes reactions occurring in mammalian cells of numerous tissue types. The iron metabolic network contains 151 chemical species and 107 reactions and transport steps. Starting from this general model, we construct iron networks for specific tissues and cells that are fundamental to maintaining body iron homeostasis. We include subnetworks for cells of the intestine and liver, tissues important in iron uptake and storage, respectively, as well as the reticulocyte and macrophage, key cells in iron utilization and recycling. The addition of kinetic information to our structural network will permit the simulation of iron metabolism in different tissues as well as in health and disease.

Graphical abstract: A general map of iron metabolism and tissue-specific subnetworks

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Article information

https://doi.org/10.1039/B816714C
Submitted
23 Sep 2008
Accepted
26 Jan 2009
First published
06 Mar 2009
Mol. BioSyst., 2009,5, 422-443
Article type
Review Article
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A general map of iron metabolism and tissue-specific subnetworks

V. Hower, P. Mendes, F. M. Torti, R. Laubenbacher, S. Akman, V. Shulaev and S. V. Torti, Mol. BioSyst., 2009, 5, 422
DOI: 10.1039/B816714C

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