Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 4, 2009
Previous Article Next Article

Protein lethality investigated in terms of long range dynamical interactions

Author affiliations

Abstract

The relationship between network structure/dynamics and biological function constitutes a fundamental issue in systems biology. However, despite many related investigations, the correspondence between structure and biological functions is not yet fully understood. A related subject that has deserved particular attention recently concerns how essentiality is related to the structure and dynamics of protein interactions. In the current work, protein essentiality is investigated in terms of long range influences in proteinprotein interaction networks by considering simulated dynamical aspects. This analysis is performed with respect to outward activations, an approach which models the propagation of interactions between proteins by considering self-avoiding random walks. The obtained results are compared to protein local connectivity. Both the connectivity and the outward activations were found to be strongly related to protein essentiality.

Graphical abstract: Protein lethality investigated in terms of long range dynamical interactions

Back to tab navigation

Article information


Submitted
08 Sep 2008
Accepted
19 Jan 2009
First published
24 Feb 2009

Mol. BioSyst., 2009,5, 385-390
Article type
Paper

Protein lethality investigated in terms of long range dynamical interactions

F. A. Rodrigues and L. D. F. Costa, Mol. BioSyst., 2009, 5, 385
DOI: 10.1039/B815702M

Search articles by author

Spotlight

Advertisements