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Issue 1, 2009
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SAC1 lipid phosphatase and growth control of the secretory pathway

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Abstract

Phosphoinositide lipids play a dual role in cell physiology. Specific sets of these molecules are short-lived downstream mediators of growth signals, regulating cell survival and differentiation. In addition, distinct classes of phosphoinositide lipids function as constitutive mediators of membrane traffic and organelle identity. Recent work has provided the first direct evidence that phosphoinositides also play a direct role in linking protein secretion with cell growth and proliferation. This review focuses on SAC1 lipid phosphatase and how this enzyme operates in an evolutionary conserved mechanism to coordinate the secretory capacity of ER and Golgi during cell growth.

Graphical abstract: SAC1 lipid phosphatase and growth control of the secretory pathway

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Publication details

The article was received on 27 Jun 2008, accepted on 25 Sep 2008 and first published on 24 Nov 2008


Article type: Review Article
DOI: 10.1039/B810979F
Mol. BioSyst., 2009,5, 36-42

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    SAC1 lipid phosphatase and growth control of the secretory pathway

    A. Blagoveshchenskaya and P. Mayinger, Mol. BioSyst., 2009, 5, 36
    DOI: 10.1039/B810979F

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