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Issue 24, 2009
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Centrifugo-pneumatic valve for metering of highly wetting liquids on centrifugal microfluidic platforms

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Abstract

We designed and experimentally validated a new type of passive valve for centrifugal microfluidic platforms. A liquid column entering an unvented receiving chamber is stopped by the counter-pressure of compressed air. This valve opens under defined conditions at high centrifugal frequencies at which the interface between liquid and air becomes unstable and enables a phase exchange, forwarding the liquid. Burst frequencies of the valve were determined for liquids typically used in biochemical assays: pure water, water with detergent concentrations between 0.01 and 10%, and pure ethanol. Burst frequencies between 8.5 ± 0.6 and 27.9 ± 2.0 Hz were measured for different surface tensions. The burst frequencies can be tuned by simple geometrical changes in the valving structure. The valve does not require ultra-precise structures or local surface modifications and is therefore ideal for low-cost microfluidic polymer disks. Potential applications are in the field of multiparameter and panel analysis, such as PCR-genotyping.

Graphical abstract: Centrifugo-pneumatic valve for metering of highly wetting liquids on centrifugal microfluidic platforms

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Article information


Submitted
17 Jul 2009
Accepted
10 Sep 2009
First published
12 Oct 2009

Lab Chip, 2009,9, 3599-3603
Article type
Technical Note

Centrifugo-pneumatic valve for metering of highly wetting liquids on centrifugal microfluidic platforms

D. Mark, T. Metz, S. Haeberle, S. Lutz, J. Ducrée, R. Zengerle and F. von Stetten, Lab Chip, 2009, 9, 3599
DOI: 10.1039/B914415C

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