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Issue 19, 2009
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Automated high-throughput cell microsurgery on-chip

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Abstract

Laser cell kill is an established tool for studying cells' roles during development and behavior, but its use has been limited due to the manual and low-throughput nature. We demonstrate here a technique combining multiplexing microfluidic manipulation of Caenorhabditis elegans and software for image processing and automation, allowing for high-throughput cell ablations.

Graphical abstract: Automated high-throughput cell microsurgery on-chip

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Article information


Submitted
02 Jun 2009
Accepted
11 Aug 2009
First published
19 Aug 2009

Lab Chip, 2009,9, 2764-2766
Article type
Communication

Automated high-throughput cell microsurgery on-chip

K. Chung and H. Lu, Lab Chip, 2009, 9, 2764
DOI: 10.1039/B910703G

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