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Issue 16, 2009
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An integrated microfluidic device for large-scale in situ click chemistry screening

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Abstract

An integrated microfluidic device has been developed to perform 1024 in situ click chemistry reactions in parallel using the bovine carbonic anhydrous II (bCAII) click chemistry system as a proof-of-concept study and a rapid hit identification approach using SPE purification and electrospray-ionization mass spectrometry, multiple reaction monitoring (MRM) analysis, all of which improves the sensitivity and throughput of the downstream analysis.

Graphical abstract: An integrated microfluidic device for large-scale in situ click chemistry screening

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Supplementary files

Article information


Submitted
14 Apr 2009
Accepted
11 Jun 2009
First published
17 Jun 2009

Lab Chip, 2009,9, 2281-2285
Article type
Communication

An integrated microfluidic device for large-scale in situ click chemistry screening

Y. Wang, W. Lin, K. Liu, R. J. Lin, M. Selke, H. C. Kolb, N. Zhang, X. Zhao, M. E. Phelps, C. K. F. Shen, K. F. Faull and H. Tseng, Lab Chip, 2009, 9, 2281
DOI: 10.1039/B907430A

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