Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 19, 2009
Previous Article Next Article

Magneto-mechanical mixing and manipulation of picoliter volumes in vesicles

Author affiliations

Abstract

Superparamagnetic beads in giant unilamellar vesicles are used to facilitate magnetic manipulation, positioning, agitation and mixing of ultrasmall liquid volumes. Vesicles act as leakproof picoliter reaction vessels in an aqueous bulk solution and can be deliberately conveyed by an external magnetic field to a designated position. Upon application of an external magnetic field the beads align to form extended chains. In a rotating magnetic field chains break up into smaller fragments caused by the interplay of viscous friction and magnetic attraction. This process obeys a simple relationship and can be exploited to enhance mixing of the vesicle content and the outer solution or adjacent vesicle volumes exactly at the position of release.

Graphical abstract: Magneto-mechanical mixing and manipulation of picoliter volumes in vesicles

Back to tab navigation

Supplementary files

Article information


Submitted
25 Nov 2008
Accepted
24 Jun 2009
First published
06 Jul 2009

Lab Chip, 2009,9, 2831-2835
Article type
Paper

Magneto-mechanical mixing and manipulation of picoliter volumes in vesicles

T. Franke, L. Schmid, D. A. Weitz and A. Wixforth, Lab Chip, 2009, 9, 2831
DOI: 10.1039/B906569P

Social activity

Search articles by author

Spotlight

Advertisements