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Issue 7, 2009
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A new USP Class VI-compliant substrate for manufacturing disposable microfluidic devices

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Abstract

As microfluidic systems transition from research tools to disposable clinical-diagnostic devices, new substrate materials are needed to meet both the regulatory requirement as well as the economics of disposable devices. This paper introduces a UV-curable polyurethane-methacrylate (PUMA) substrate that has been qualified for medical use and meets all of the challenges of manufacturing microfluidic devices. PUMA is optically transparent, biocompatible, and exhibits high electroosmotic mobility without surface modification. We report two production processes that are compatible with the existing methods of rapid prototyping and present characterizations of the resultant PUMA microfluidic devices.

Graphical abstract: A new USP Class VI-compliant substrate for manufacturing disposable microfluidic devices

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Article information


Submitted
24 Oct 2008
Accepted
22 Jan 2009
First published
10 Feb 2009

Lab Chip, 2009,9, 870-876
Article type
Paper

A new USP Class VI-compliant substrate for manufacturing disposable microfluidic devices

J. S. Kuo, L. Ng, G. S. Yen, R. M. Lorenz, P. G. Schiro, J. S. Edgar, Y. Zhao, D. S. W. Lim, P. B. Allen, G. D. M. Jeffries and D. T. Chiu, Lab Chip, 2009, 9, 870
DOI: 10.1039/B818873D

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