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Issue 21, 2009
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Three-dimensional hydrodynamic focusing with a single sheath flow in a single-layer microfluidic device

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Abstract

We report a contraction–expansion array (CEA) microchannel that allows three-dimensional hydrodynamic focusing with a single sheath flow in a single-layer device. The CEA microchannel exploits centrifugal forces acting on fluids travelling along the contraction and expansion regions of the microchannel. Around an entrance of the contraction region, the centrifugal forces induce a secondary flow field where two counter-rotating vortices enable to envelop a sample flow with a sheath flow in three dimensions. We herein describe an underlying principle and a design of the CEA microchannel and demonstrate complete sheathing of a sample fluid (water and human red blood cells) in three dimensions. The focusing characteristics of the CEA microchannel are investigated in terms of the number of the rectangular structures, flow rate, and flow ratio between sample and sheath flows. This microfluidic channel for three-dimensional hydrodynamic focusing is easy to fabricate in a single-layer fabrication process and simple to operate with a single sheath flow.

Graphical abstract: Three-dimensional hydrodynamic focusing with a single sheath flow in a single-layer microfluidic device

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Article information


Submitted
01 Jun 2009
Accepted
28 Jul 2009
First published
10 Aug 2009

Lab Chip, 2009,9, 3155-3160
Article type
Technical Note

Three-dimensional hydrodynamic focusing with a single sheath flow in a single-layer microfluidic device

M. G. Lee, S. Choi and J. Park, Lab Chip, 2009, 9, 3155
DOI: 10.1039/B910712F

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