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Issue 11, 2009
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Plastic–PDMS bonding for high pressure hydrolytically stable active microfluidics

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Abstract

We explore the application of organofunctional silanes for bonding plastic substrates to PDMS membranes. Such devices would enable actuated membrane microfluidics in plastic devices. Bond strength degradation in aqueous environments can be reduced by using bis-silanes with larger alkoxy end groups to promote organofunctional bond formation with the plastic substrate. Hydrolytic failure can also result from low silane crosslink density or interface hydrophilicity. A test device consisting of three-valve peristaltic pumps is fabricated out of polycarbonate (PC) and bonded to PDMS through isopropoxy modified bis-trimethoxy-silyl-propyl-amine. Valves operated up to 60 psi in aqueous environments without failure. Solutions of DI water and 1 M HCl were also pumped through the device via peristaltic actuation at 18 psi for 2 weeks without bond failure. 1 M NaOH was also tested but resulted in bond failure after 115 hours.

Graphical abstract: Plastic–PDMS bonding for high pressure hydrolytically stable active microfluidics

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Article information


Submitted
24 Nov 2008
Accepted
23 Feb 2009
First published
13 Mar 2009

Lab Chip, 2009,9, 1618-1624
Article type
Paper

Plastic–PDMS bonding for high pressure hydrolytically stable active microfluidics

K. S. Lee and R. J. Ram, Lab Chip, 2009, 9, 1618
DOI: 10.1039/B820924C

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