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Issue 35, 2009
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Imaging gold nanorods in excised human breast carcinoma by spectroscopic optical coherence tomography

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Abstract

Plasmon-resonant gold nanorods (GNRs) can serve as imaging agents for spectroscopic optical coherence tomography (SOCT). The aspect ratio of the GNRs is adjusted for maximum absorption in the far red to create a partial spectral overlap with the short-wavelength edge of the near-infrared SOCT imaging band. The spectroscopic absorption profile of the GNRs is incorporated into a depth-resolved algorithm for mapping the relative GNR density within OCT images. This technique enables us to image GNR distributions in excised human breast carcinomas, demonstrating their potential as OCT contrast agents in heterogeneous, highly scattering tissues.

Graphical abstract: Imaging gold nanorods in excised human breast carcinoma by spectroscopic optical coherence tomography

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Article information


Submitted
06 Jan 2009
Accepted
06 Mar 2009
First published
20 Apr 2009

J. Mater. Chem., 2009,19, 6407-6411
Article type
Paper

Imaging gold nanorods in excised human breast carcinoma by spectroscopic optical coherence tomography

A. L. Oldenburg, M. N. Hansen, T. S. Ralston, A. Wei and S. A. Boppart, J. Mater. Chem., 2009, 19, 6407
DOI: 10.1039/B823389F

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