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Issue 19, 2009
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Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer

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Abstract

We fabricated de novo biocompatible mineral plasmon resonants for localized and systemic treatment of cancer. Biodegradable calcium-phosphate gold nanocomposites were synthesized for inducing a superior surface plasmon resonance effect. The combination of therapeutic antibody, Erbitux® and NIR laser with nanocomposites demonstrated the potential for selective bimodal cancer treatment by combination of EGFR-induced signaling inhibition as a systemic treatment and localized photothermal effects caused by the NIR laser.

Graphical abstract: Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer

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Publication details

The article was received on 19 Dec 2008, accepted on 24 Mar 2009 and first published on 06 Apr 2009


Article type: Communication
DOI: 10.1039/B822835C
J. Mater. Chem., 2009,19, 2902-2905

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    Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer

    J. Kang, J. Yang, J. Lee, S. J. Oh, S. Moon, H. J. Lee, S. C. Lee, J. Son, D. Kim, K. Lee, J. Suh, Y. Huh and S. Haam, J. Mater. Chem., 2009, 19, 2902
    DOI: 10.1039/B822835C

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