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Issue 19, 2009
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Green nanotechnology from tea: phytochemicals in tea as building blocks for production of biocompatible gold nanoparticles

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Abstract

Phytochemicals occluded in tea have been extensively used as dietary supplements and as natural pharmaceuticals in the treatment of various diseases including human cancer. Results on the reduction capabilities of phytochemicals present in tea to reduce gold salts to the corresponding gold nanoparticles are presented in this paper. The phytochemicals present in tea serve a dual role as effective reducing agents to reduce gold and also as stabilizers to provide a robust coating on the gold nanoparticles in a single step. The tea-generated gold nanoparticles (T-AuNPs), have demonstrated remarkable in vitro stability in various buffers including saline, histidine, HSA, and cysteine solutions. T-AuNPs with phytochemical coatings have shown significant affinity toward prostate (PC-3) and breast (MCF-7) cancer cells. Results on the cellular internalization of T-AuNPs through endocytosis into the PC-3 and MCF-7 cells are presented. The generation of T-AuNPs follows all principles of green chemistry and T-AuNPs have been found to be non toxic as assessed through MTT assays. No ‘man made’ chemicals, other than gold salts, are used in this truly biogenic, green nanotechnological process thus paving the way for excellent opportunities for their application in molecular imaging and therapy.

Graphical abstract: Green nanotechnology from tea: phytochemicals in tea as building blocks for production of biocompatible gold nanoparticles

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Supplementary files

Article information


Submitted
08 Dec 2008
Accepted
05 Feb 2009
First published
11 Mar 2009

J. Mater. Chem., 2009,19, 2912-2920
Article type
Paper

Green nanotechnology from tea: phytochemicals in tea as building blocks for production of biocompatible gold nanoparticles

S. K. Nune, N. Chanda, R. Shukla, K. Katti, R. R. Kulkarni, S. Thilakavathy, S. Mekapothula, R. Kannan and K. V. Katti, J. Mater. Chem., 2009, 19, 2912
DOI: 10.1039/B822015H

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