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Issue 1, 2009
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Phosphonate monolayers functionalized by silver thiolate species as antibacterial nanocoatings on titanium and stainless steel

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Abstract

Titanium and stainless steel substrates were modified by grafting with mercaptododecylphosphonic acid (MDPA) followed by reaction with silver nitrate (AgNO3), in order to investigate the potential of phosphonate self-assembled monolayers functionalized by silver thiolate species as antibacterial nanocoatings for inorganic biomaterials. The samples were characterized by Fourier transform infrared (FTIR) spectroscopy in grazing-incidence mode, water contact angle measurements, and X-ray photoelectron spectroscopy (XPS). The influence of the surface modification on bacterial adhesion and biofilm growth was investigated in vitro using Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis, and Staphylococcus aureus strains. The stability of the monolayer in blood-mimicking medium was examined. Despite their very low silver content, MDPA + AgNO3 monolayers strongly decreased bacterial adhesion (>99.9% reduction in the number of viable adherent bacteria) and biofilm formation in comparison to the bare substrates.

Graphical abstract: Phosphonate monolayers functionalized by silver thiolate species as antibacterial nanocoatings on titanium and stainless steel

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Supplementary files

Article information


Submitted
01 Aug 2008
Accepted
17 Oct 2008
First published
14 Nov 2008

J. Mater. Chem., 2009,19, 141-149
Article type
Paper

Phosphonate monolayers functionalized by silver thiolate species as antibacterial nanocoatings on titanium and stainless steel

J. Amalric, P. H. Mutin, G. Guerrero, A. Ponche, A. Sotto and J. Lavigne, J. Mater. Chem., 2009, 19, 141
DOI: 10.1039/B813344A

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