The Rover Environmental Monitoring Station (REMS) is one of NASA/MSL's instruments, which has been designed for measuring ambient pressure, humidity, wind speed and direction, UV radiation, and air and ground temperature (GT). The GT-sensor is dedicated to measure the real temperature of the Martian surface, integrating the IR energy coming from the ground. The existing IR spectral data of Martian dust, rocks and sediments allow for comparing the Martian spectra with the spectra of different terrestrial minerals and lithologies, and those of their alteration and weathering products. The FTIR reflectance of a set of selected astrobiologically significant minerals (including oxides, oxi/hydroxides, sulfates, chlorides, opal and clays) and basalt (as the main and most widespread volcanic Martian rock) was measured, considering different mixing amounts, and covering the specific working wavelength range of the REMS' GT-sensor. The results obtained show important percentage increases or decreases of reflectance in the entire wavelength range (e.g. basalt–hematitevs. basalt–magnetite) and specific variations limited to some spectral bands (e.g. basalt–smectite vs. basalt–jasper). The basalt reflectance percentage increases or decreases, even up to 100%, depending on the mixing of the different minerals. This unequivocally confirms the need for considering the chemical–mineralogical assemblages (and their textures) for any investigation and interpretation of Mars surface environment. Some complementary applications of this research on our planet, either in relation to the specific performances and characteristics of the GT-sensor autonomous recalibration system, or those oriented to carrying out similar studies on different types of terrestrial environmental settings, are also described.