Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 48, 2009
Previous Article Next Article

Cytotoxicity, cellular localisation and biomolecular interaction of non-covalent metallo-intercalators with appended sex hormonesteroid vectors

Author affiliations

Abstract

A range of terpyridine platinum(II) metallo-intercalators with bioactive steroids attached has been created with the aim of localizing cytotoxic drugs. Complexes where the steroid does not interfere with access to the terpyridine are shown to retain potent cytotoxicity and show certain selectivity towards their natural receptors. Because the intercalation of the terpyridine moiety between the bases of the DNA is the origin of the biological activity, a dramatic decrease of the activity is observed when the access to the terpyridine unit is hindered by the steroidal unit.

Graphical abstract: Cytotoxicity, cellular localisation and biomolecular interaction of non-covalent metallo-intercalators with appended sex hormone steroid vectors

Back to tab navigation

Supplementary files

Article information


Submitted
26 Jun 2009
Accepted
24 Sep 2009
First published
16 Oct 2009

Dalton Trans., 2009, 10765-10773
Article type
Paper

Cytotoxicity, cellular localisation and biomolecular interaction of non-covalent metallo-intercalators with appended sex hormone steroid vectors

C. Sánchez-Cano and M. J. Hannon, Dalton Trans., 2009, 10765
DOI: 10.1039/B912711A

Social activity

Search articles by author

Spotlight

Advertisements