Jump to main content
Jump to site search

Issue 45, 2009
Previous Article Next Article

Transcriptional regulation of the cyanobacterial bidirectional Hox-hydrogenase

Author affiliations

Abstract

The overall processes of transcription and its regulation have advanced significantly in the last years, making our understanding of prokaryotic biology more complex and detailed. In fact, a systematic study of different aspects of transcriptional regulation opens up outstanding opportunities to improve and develop the perception of complex reaction mechanisms, genetic processes and cell functions. In close connection to the cyanobacterial bidirectional hydrogenase, the main hydrogen-evolving enzyme in non-nitrogen fixing strains, two novel transcription factors have received increasing attention over the past five years: a LexA-related protein and the AbrB-like family members. Recent work on these regulators has produced new insights and advances towards the understanding (and possible interconnection) of several regulatory networks in cyanobacteria, namely nitrogen metabolism, redox response, toxin production, CO2 concentrating mechanisms and hydrogen metabolism. The fact that a LexA-related protein and AbrB-like family members have been co-purified in independent laboratories studying different sets of cyanobacterial genes suggests a possible common and/or complementary function of these regulators. In this review, we summarize the knowledge gained thus far regarding the transcriptional regulation of the cyanobacterial bidirectional hydrogenase, with special focus on the above mentioned transcription factors. Moreover, we discuss several additional points that warrants further investigation to increase our knowledge in this fast evolving research field.

Graphical abstract: Transcriptional regulation of the cyanobacterial bidirectional Hox-hydrogenase

Back to tab navigation

Publication details

The article was received on 30 Apr 2009, accepted on 21 Aug 2009 and first published on 09 Sep 2009


Article type: Perspective
DOI: 10.1039/B908593A
Dalton Trans., 2009, 9990-9996

  •   Request permissions

    Transcriptional regulation of the cyanobacterial bidirectional Hox-hydrogenase

    P. Oliveira and P. Lindblad, Dalton Trans., 2009, 9990
    DOI: 10.1039/B908593A

Search articles by author

Spotlight

Advertisements