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Issue 25, 2009
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Effect of bridging ligand structure on the thermal stability and DNA binding properties of iron(II) triple helicates

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Abstract

Triple helical di-iron complexes, readily prepared through interaction of iron(II) ions with imine-based ligands, are cylinder-shaped tetracations comparable in size and shape to common protein DNA recognition units. They have a strong tendency to coil DNA, and have recently been found to induce formation of three-way junctions in palindromic oligonucleotides. To introduce potential H bond acceptor units onto the surface of triple-helicates, new iron(II) complexes have been synthesized in which the central linking unit in the bridging ligand is S or O, instead of CH2. The DNA binding properties of these new metallo-helicates were studied using UV-vis spectroscopy and circular and linear dichroism. Results show that the three iron triple helicates bind the DNA in a similar way but that the stability of the triple helicate unit is decreased with the O linked bridging ligand.

Graphical abstract: Effect of bridging ligand structure on the thermal stability and DNA binding properties of iron(ii) triple helicates

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Publication details

The article was received on 09 Dec 2008, accepted on 03 Apr 2009 and first published on 07 May 2009


Article type: Paper
DOI: 10.1039/B822039E
Dalton Trans., 2009, 4868-4874

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    Effect of bridging ligand structure on the thermal stability and DNA binding properties of iron(II) triple helicates

    Y. Parajó, J. Malina, I. Meistermann, G. J. Clarkson, M. Pascu, A. Rodger, M. J. Hannon and P. Lincoln, Dalton Trans., 2009, 4868
    DOI: 10.1039/B822039E

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