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Issue 11, 2009
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The economies of synthesis

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Abstract

In this tutorial review the economies of synthesis are analysed from both detailed and macroscopic perspectives, using case-studies from complex molecule synthesis. Atom, step, and redox economy are more than philosophical constructs, but rather guidelines, which enable the synthetic chemist to design and execute an efficient synthesis. Students entering the field of synthesis might find this tutorial helpful for understanding the subtle differences between these economic principles and also see real-world situations where such principles are put into practice.

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Article information


Submitted
05 May 2009
First published
21 Aug 2009

Chem. Soc. Rev., 2009,38, 3010-3021
Article type
Tutorial Review

The economies of synthesis

T. Newhouse, P. S. Baran and R. W. Hoffmann, Chem. Soc. Rev., 2009, 38, 3010
DOI: 10.1039/B821200G

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