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Issue 8, 2009
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A microbial polyhydroxyalkanoates (PHA) based bio- and materials industry

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Abstract

Biopolyesters polyhydroxyalkanoates (PHA) produced by many bacteria have been investigated by microbiologists, molecular biologists, biochemists, chemical engineers, chemists, polymer experts and medical researchers. PHA applications as bioplastics, fine chemicals, implant biomaterials, medicines and biofuels have been developed and are covered in this critical review. Companies have been established or involved in PHA related R&D as well as large scale production. Recently, bacterial PHA synthesis has been found to be useful for improving robustness of industrial microorganisms and regulating bacterial metabolism, leading to yield improvement on some fermentation products. In addition, amphiphilic proteins related to PHA synthesis including PhaP, PhaZ or PhaC have been found to be useful for achieving protein purification and even specific drug targeting. It has become clear that PHA and its related technologies are forming an industrial value chain ranging from fermentation, materials, energy to medical fields (142 references).

Graphical abstract: A microbial polyhydroxyalkanoates (PHA) based bio- and materials industry

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Publication details

The article was received on 05 Jan 2009 and first published on 08 May 2009


Article type: Critical Review
DOI: 10.1039/B812677C
Chem. Soc. Rev., 2009,38, 2434-2446

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    A microbial polyhydroxyalkanoates (PHA) based bio- and materials industry

    G. Chen, Chem. Soc. Rev., 2009, 38, 2434
    DOI: 10.1039/B812677C

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