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Issue 9, 2009
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Selectively functionalized cyclodextrins and their metal complexes

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Abstract

Cyclodextrins (CDs) are cyclic oligomers of α-1,4-linked D-glucopyranose. Due to their unique structure, marked by a chiral and hydrophobic cavity, CDs have been extensively used as chiral selectors and drug delivery systems. The functionalization both improve the CD applications and widen their use in many other fields, such as molecular recognition and enzyme mimicking. Moreover, the functionalization highly increases the metal binding properties of the CDs. This critical review is a report of recent applications concerning the CD derivatives and their metal complexes. The metal ion assists the host–guest interaction often increasing the properties of CDs to act as chiral receptors. Furthermore, it can act as a catalytic center in the mimicking of metalloenzymes based on functionalized CDs (164 references).

Graphical abstract: Selectively functionalized cyclodextrins and their metal complexes

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Article information


Submitted
03 Feb 2009
First published
30 Jun 2009

Chem. Soc. Rev., 2009,38, 2756-2781
Article type
Critical Review

Selectively functionalized cyclodextrins and their metal complexes

F. Bellia, D. La Mendola, C. Pedone, E. Rizzarelli, M. Saviano and G. Vecchio, Chem. Soc. Rev., 2009, 38, 2756
DOI: 10.1039/B718436K

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