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Issue 8, 2009
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Chiral Brønsted acid catalyzed Friedel–Crafts alkylation reactions

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Abstract

The asymmetric Friedel–Crafts reaction is one of the most powerful methods to synthesize optically active aromatic compounds. Particularly, the Friedel–Crafts alkylation of arenes with unsaturated compounds activated by chiral Brønsted acids provides direct access to enantiopure aromatic derivatives with perfect atom economy. In this tutorial review, recent progress in the development of chiral Brønsted acid-catalyzed asymmetric Friedel–Crafts reactions is presented.

Graphical abstract: Chiral Brønsted acid catalyzed Friedel–Crafts alkylation reactions

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Article information


Submitted
15 Jan 2009
First published
07 Apr 2009

Chem. Soc. Rev., 2009,38, 2190-2201
Article type
Tutorial Review

Chiral Brønsted acid catalyzed Friedel–Crafts alkylation reactions

S. You, Q. Cai and M. Zeng, Chem. Soc. Rev., 2009, 38, 2190
DOI: 10.1039/B817310A

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