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Issue 8, 2009
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Nanopore analytics: sensing of single molecules

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Abstract

In nanopore analytics, individual molecules pass through a single nanopore giving rise to detectable temporary blockades in ionic pore current. Reflecting its simplicity, nanopore analytics has gained popularity and can be conducted with natural protein as well as man-made polymeric and inorganic pores. The spectrum of detectable analytes ranges from nucleic acids, peptides, proteins, and biomolecular complexes to organic polymers and small molecules. Apart from being an analytical tool, nanopores have developed into a general platform technology to investigate the biophysics, physicochemistry, and chemistry of individual molecules (critical review, 310 references).

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Article information


Submitted
17 Feb 2009
First published
15 Jun 2009

Chem. Soc. Rev., 2009,38, 2360-2384
Article type
Critical Review

Nanopore analytics: sensing of single molecules

S. Howorka and Z. Siwy, Chem. Soc. Rev., 2009, 38, 2360
DOI: 10.1039/B813796J

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