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Issue 8, 2009
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Asymmetric hydrogenation, transfer hydrogenation and hydrosilylation of ketones catalyzed by iron complexes

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Abstract

The conventional homogeneous catalysts for the enantioselective hydrogenation or transfer hydrogenation of ketones are based on platinum metals and, in particular, ruthenium. This method provides valuable enantiopure alcohols for the fine chemical industries. This tutorial review summarizes recent successes in replacing expensive and toxic ruthenium in these catalysts with “greener” iron substitutes including my lab’s recent progress in this area using iron complexes containing readily-prepared tetradentate ligands. It will enlighten chemists interested in homogeneous catalysis and asymmetric synthesis.

Graphical abstract: Asymmetric hydrogenation, transfer hydrogenation and hydrosilylation of ketones catalyzed by iron complexes

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Article information


Submitted
25 Feb 2009
First published
28 May 2009

Chem. Soc. Rev., 2009,38, 2282-2291
Article type
Tutorial Review

Asymmetric hydrogenation, transfer hydrogenation and hydrosilylation of ketones catalyzed by iron complexes

R. H. Morris, Chem. Soc. Rev., 2009, 38, 2282
DOI: 10.1039/B806837M

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