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Issue 2, 2009
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Molecular recognition of bilayer vesicles

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Abstract

Vesicles have been a versatile topic of research in chemistry ever since the discovery that, besides phospholipids, synthetic amphiphiles can also form molecular bilayers enclosing a small aqueous compartment. Non-covalent interactions of receptors and ligands or hosts and guests at vesicle surfaces resemble recognition processes at biological membranes, including cell recognition, adhesion and fusion. Molecular recognition at membranes is often mediated by a multivalent instead of a monovalent interaction. This tutorial review describes the basics as well as the latest developments in biomimetic supramolecular chemistry of bilayer vesicles. We describe how molecular recognition can mediate the interaction between vesicles, and how the biomimetic supramolecular chemistry of vesicles furthers our understanding of biological membranes.

Graphical abstract: Molecular recognition of bilayer vesicles

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Publication details

The article was received on 25 Aug 2008 and first published on 22 Dec 2008


Article type: Tutorial Review
DOI: 10.1039/B803782P
Chem. Soc. Rev., 2009,38, 495-505

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    Molecular recognition of bilayer vesicles

    J. Voskuhl and B. J. Ravoo, Chem. Soc. Rev., 2009, 38, 495
    DOI: 10.1039/B803782P

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