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Issue 2, 2009
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Asymmetric organocatalysis by chiral Brønsted bases: implications and applications

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Abstract

Chiral, metal-free Brønsted bases have been demonstrated capable of catalyzing several types of CC and CX bond-forming reactions with high chemical and stereochemical efficiency, thereby complementing other major organocatalytic asymmetric approaches such as enamine catalysis. This critical review describes the most fundamental developments in the area, which have been documented in the last couple of years, along with major mechanistic implications. Discussion includes the limitations of the present protocols, identifies the most salient gaps, and gives a prospect of future improvements and applications (122 references).

Graphical abstract: Asymmetric organocatalysis by chiral Brønsted bases: implications and applications

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Publication details

The article was received on 30 Jul 2008 and first published on 19 Dec 2008


Article type: Critical Review
DOI: 10.1039/B708453F
Chem. Soc. Rev., 2009,38, 632-653

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    Asymmetric organocatalysis by chiral Brønsted bases: implications and applications

    C. Palomo, M. Oiarbide and R. López, Chem. Soc. Rev., 2009, 38, 632
    DOI: 10.1039/B708453F

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