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Issue 2, 2009
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Putting pressure on elusive polymorphs and solvates

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Abstract

The reproducible crystallisation of elusive polymorphs and solvates of molecular compounds at high pressure has been demonstrated through studies on maleic acid, malonamide, and paracetamol. These high-pressure methods can be scaled-up to produce ‘bulk’ quantities of metastable forms that can be recovered to ambient pressure for subsequent seeding experiments. This has been demonstrated for paracetamol form II and paracetamol monohydrate. The studies also show that the particular solid form can be tuned by both pressure and concentration.

Graphical abstract: Putting pressure on elusive polymorphs and solvates

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Article information


Submitted
20 Aug 2008
Accepted
28 Oct 2008
First published
28 Nov 2008

CrystEngComm, 2009,11, 359-366
Article type
Paper

Putting pressure on elusive polymorphs and solvates

I. D. H. Oswald, I. Chataigner, S. Elphick, F. P. A. Fabbiani, A. R. Lennie, J. Maddaluno, W. G. Marshall, T. J. Prior, C. R. Pulham and R. I. Smith, CrystEngComm, 2009, 11, 359
DOI: 10.1039/B814471K

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