Issue 47, 2009
From the journal:

Chemical Communications

Products of the iterative polyketide synthases in 9- and 10-membered enediyne biosynthesis†

Huihua Sun,a   Rong Kong,a   Di Zhu,b   Min Lu,b   Qiang Ji,a   Chong Wai Liew,a   Julien Lescar,a   Guofu Zhong*b  and  Zhao-Xun Liang*a  

* Corresponding authors

a School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551
E-mail: zxliang@ntu.edu.sg

b Division of Chemistry & Biological Chemistry, School of Physics & Mathematics Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371
E-mail: Guofu@ntu.edu.sg

Abstract

The iterative polyketide synthases from the biosynthetic pathways of three enediyne natural products were examined. The results established the all-trans conjugated pentadecaheptanene as the only major product shared by the PKSs. The experiments further revealed some intrinsic differences among the PKSs by demonstrating the formation of different by-products.

Graphical abstract: Products of the iterative polyketide synthases in 9- and 10-membered enediyne biosynthesis

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Article information

DOI
https://doi.org/10.1039/B916751J
Article type
Communication
Submitted
14 Aug 2009
Accepted
13 Oct 2009
First published
27 Oct 2009

Chem. Commun., 2009, 7399-7401

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Products of the iterative polyketide synthases in 9- and 10-membered enediyne biosynthesis

H. Sun, R. Kong, D. Zhu, M. Lu, Q. Ji, C. W. Liew, J. Lescar, G. Zhong and Z. Liang, Chem. Commun., 2009, 7399 DOI: 10.1039/B916751J

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