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Issue 41, 2009
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NeoPHOX—an easily accessible P,N-ligand for iridium-catalyzed asymmetric hydrogenation: preparation, scope and application in the synthesis of demethyl methoxycalamenene

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Abstract

Using a new class of chiral iridium hydrogenation catalysts, the antitumor natural product demethyl calamenene was synthesized in four steps in >20% overall yield and high enantiomeric purity.

Graphical abstract: NeoPHOX—an easily accessible P,N-ligand for iridium-catalyzed asymmetric hydrogenation: preparation, scope and application in the synthesis of demethyl methoxycalamenene

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Article information


Submitted
26 Jun 2009
Accepted
14 Aug 2009
First published
27 Aug 2009

Chem. Commun., 2009, 6210-6212
Article type
Communication

NeoPHOX—an easily accessible P,N-ligand for iridium-catalyzed asymmetric hydrogenation: preparation, scope and application in the synthesis of demethyl methoxycalamenene

M. G. Schrems and A. Pfaltz, Chem. Commun., 2009, 6210
DOI: 10.1039/B912680E

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