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Issue 39, 2009
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Solid-state interactions of calixarenes with biorelevant molecules

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Abstract

Among all crystalline complexes of calix-type calix[n]arenes those with organic molecules which are biologically relevant are especially of interest due to their potential medical and pharmaceutical applications. The co-crystallization of drugs with water-soluble calixarenes offers the opportunity to modify chemical and physical properties of APIs (active pharmaceutical ingredients) and to control drug conformation. Such co-crystallization can improve solubility, bioavailability and stability of pharmaceutically active molecules and/or eliminate polymorphism. In this article the solid-state interactions between calixarene hosts and biologically relevant guest molecules are summarized for the currently available structures solved by single-crystal X-ray crystallography.

Graphical abstract: Solid-state interactions of calixarenes with biorelevant molecules

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Article information


Submitted
27 May 2009
Accepted
21 Jul 2009
First published
19 Aug 2009

Chem. Commun., 2009, 5799-5813
Article type
Feature Article

Solid-state interactions of calixarenes with biorelevant molecules

O. Danylyuk and K. Suwinska, Chem. Commun., 2009, 5799 DOI: 10.1039/B910331G

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