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Issue 35, 2009
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Phosphine-mediated one-pot thiol–ene “click” approach to polymer–protein conjugates

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Abstract

We employ water-soluble organic phosphines as key reagents in a one-pot synthetic protocol where a (poly)peptide disulfide bridge is first reduced followed by subsequent reaction of the two thiols in situ with poly(monomethoxy ethylene glycol)(meth)acrylates (p(mPEG)(M)A); we use salmon calcitonin (sCT) as a disulfide bridge-containing peptide, which contains a disulfide bridge—Cys1–Cys7—that can be reduced to give two sulfhydryl units available for thiol functionalisation; bioactivity is retained.

Graphical abstract: Phosphine-mediated one-pot thiol–ene “click” approach to polymer–protein conjugates

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Publication details

The article was received on 06 Apr 2009, accepted on 30 Jun 2009 and first published on 21 Jul 2009


Article type: Communication
DOI: 10.1039/B906865A
Chem. Commun., 2009, 5272-5274

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    Phosphine-mediated one-pot thiol–ene “click” approach to polymerprotein conjugates

    M. W. Jones, G. Mantovani, S. M. Ryan, X. Wang, D. J. Brayden and D. M. Haddleton, Chem. Commun., 2009, 5272
    DOI: 10.1039/B906865A

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